L-Canavanine sulfate
L-Canavanine Sulfate
CAS: 2219-31-0
Molecular Formula: C5H14N4O7S
L-Canavanine sulfate - Names and Identifiers
L-Canavanine sulfate - Physico-chemical Properties
| Molecular Formula | C5H14N4O7S |
| Molar Mass | 274.25 |
| Melting Point | 160-165°C (dec.) |
| Boling Point | 574°C at 760mmHg |
| Solubility | Soluble in water and ethanol |
| Appearance | White powder |
| Color | white |
| BRN | 6121291 |
| Storage Condition | 2-8°C |
| Sensitive | Air `sensitive` seal |
| MDL | MFCD00012618 |
| In vitro study | L-Canavanine sulfate (L-CAV) causes only a limited degree of cytotoxicity in HeLa, Hep G2, and SK-HEP-1 cells when given alone in arginine-rich media with IC 50 values ranging from 5 to 10 mM. In HaCaT keratinocyte cell line, IC 50 of L-Canavanine sulfate exceeds the concentration of 10 mM, indicating low cytotoxicity in normal cells in vitro . In arginine-free media, IC 50 of L-Canavanine sulfate in HeLa, Hep G2, and SK-HEP-1 cells are 0.21±0.04; 0.64±0.16; and 1.18±0.14 mM, respectively. L-Canavanine sulfate, which is hardly toxic alone, potentiates the cytotoxicity of vinblastine (VIN) and paclitaxel (PTX) in HeLa and hepatocellular carcinoma cells. |
| In vivo study | Administration of L-Canavanine sulfate (100 mg/kg) produces a moderate increase in mean arterial pressure of 20 mm Hg, returns blood pressure to near basal levels and completely attenuates the lipopolysaccharide-induced hypotension. All, but one, endotoxaemic rats dosed with L-Canavanine sulfate (100 mg/kg) survive for 6 h post lipopolysaccharide, after which time the experiment is terminated (n=7). L-canavanine inhibits DNA synthesis by Li 210 cells in vivo and significantly increases the lifespan of animals bearing the Li 210 leukemia. An optimal dose of 18 g/kg produces a peak increase in lifespan of 44%. The therapeutic dose range is narrow, and a dose of 24 g/kg causes death due to drug toxicity. |
L-Canavanine sulfate - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| UN IDs | 2811 |
| WGK Germany | 3 |
L-Canavanine sulfate - Reference Information
| biological activity | L-Canavanine sulfate are selective inhibitors of inducible NO synthase (NO synthase). |
| target | NO synthase |
| in vitro study | L-Canavanine sulfate (L-CAV) cause only a limited degree of cytotoxicity in HeLa, Hep G2, and SK-HEP-1 cells when given alone in arginine-rich media with IC 50 values ranging from 5 to 10 mM. In HaCaT keratinocyte cell line, IC 50 of L-Canavanine sulfate exceeds the concentration of 10 mM, indicating low cytotoxicity in normal cells in vitro . In arginine-free media, IC 50 of L-Canavanine sulfate in HeLa, Hep G2, and SK-HEP-1 cells are 0.21±0.04; 0.64±0.16; And 1.18±0.14 mM, respectively. L-Canavanine sulfate, which is hard toxic alone, potentiates the cytotoxicity of vinblastine (VIN) and paclitaxel (PTX) in HeLa and hepatocellular carcinoma cells. |
| in vivo study | Administration of L-Canavanine sulfate (100 mg/kg) produces a moderate increase in mean arterial pressure of 20mm Hg, returns blood pressure to near basic levels and completely attenuates the lipopolysaccharide-induced hypotension. All, but one, endotoxaemic with L-Canavanine sulfate (100 mg/kg) survive for 6 h post lipopolysaccharide, after which time the experiment is terminated (n = 7). L-canavanine inhibits DNA synthesis by Li 210 cells in vivo and significantly increases the lifespan of animals bearing the Li 210 leukemia. an optimal dose of 18 g/kg produces a peak increase in lifespan of 44%. the therapeutic dose range is narrow, and a dose of 24 g/kg cause death due to drug toxicity. |
| EPA chemical information | information is: offered by ofmpub.epa.gov (external link) |
Last Update：2024-04-09 21:21:28
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CAS: 2219-31-0
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CAS: 2219-31-0
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Mobile: 18021002903
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